Synthesis of 1-methoxy-2-indanone

Synthesis of 1-methoxy-2-indanone Ex. 1 As chief scientific incumbent of Mark, Inc. R&D, I have the responsibility of reviewing proposed syntheses for innovative drugs that our company wishes to develop. Our president has identify 1-methoxy-2-indanone as a craved target, and two groups in our R&D division have proposed syntheses for this molecule. After mensurable evaluation, I have selected the entailment from Research host A as the one well-nigh likely to achieve success. Two steps in the proposition from Research Group B have problems that allow answer those steps, and hence the boilers suit synthesis, to fail. In step 1, the use of Br2 in the presence of FeBr3 will result in bromination of the aromatic recall to repay 5-bromoindane or else than 1-bromoindane. Had Br2 in the presence of ultraviolet well-defined been employed instead, the reply would likely have succeeded to give the desire 1-bromoindane. Each of the conterminous three ste ps from group B would give the verbalise product from the say matchant, although I do not pick up why group B would unavoidableness to prepare indane-1,2-dione (the stated product from step 4). Certainly, the closing step would not get 1-methoxy-2-indanone from indane-1,2-dione.

Lithium aluminum hydride is a powerful reducing agent, and two ketone groups would be reduced to alcohols to give 1,2-dihydroxyindane as the final product. Furthermore, the protic solving methanol is likely to react with LiAlH4 as well. All-in-all, step 5 would be a messy reaction. I respectfully disagree with our president that 1-methoxy-2-indanone is a thoroughly candidate for synthesis. many another (prenominal) over-the-counter NSAIDs such as! aspirin, ibuprofen, and naproxen contain carboxyl acid groups, and our target molecule does not. I strongly progress research group A to clear a essential literature search prior to commit the time, effort, and material be needed to synthesize 1-methoxy-2-indanone. In addition, I... If you want to get a full essay, order it on our website: OrderEssay.net

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