Denosumab

BUS 690 Case #2: Forecasting Denosumab Amgen was one of the homos leading biotech companies, with more than 17,000 employees and almost $15 billion in revenue. Amgens most important drugs put up in: * Aranesp-anemia; declining sharply * Epogen-anemia * Enbrel-arthritis * Neulasta-febrile neutropenia, a experimental condition associated with chemotherapy Amgen has developed a unseasoned yield called Denosumab under home run names Prolia and Xgeva, and had patents that were scheduled to come about betwixt 2017 and 2023. Prolia treats Osteoporosis, a bone dis erect, common but effective condition. Xgeva seeks to go along skeletal-related events from occurring in cancer patients with bone metastases. Prolia Osteoporosis is diagnosed by BMDbone mineral minginess mental riddle, the primary BMD show was dual-energy X-ray absorptiometry (DXA); a BMD test costs $50 per patient. Amgen priced Prolia at $825 per injection, or $1,650 per year. There is a total of 30.7 one grand million people in the U.S. with osteoporosis or osteopenia, and 15.5 million (49%) were diagnosed, lonesome(prenominal) a portion of that gathering received intervention. 40% of patients receiving stop continued to see declining BMD levels, and 5% had fractures.

Aside from treatment options of form and dietary supplements, bisphosphonates are the principal(prenominal) class of drugs for the treatment of osteopenia and osteoporosis in early 2011, made from deuce phosphonic groups. The drugs worked by subnormality the breakdown of bone by osteoclasts, resulting in an increase in BMD and a decrease in fractures. scorn the strong dexterity of bisphosphonates, compliance was low; studies indicated that about 50% of patients discontinued oral trial bisphosphonate therapy within the first year. Prolias competition: | U.S. Sales (mil) | variability| Boniva| $600.00 | 2008| Reclast| $579.00 | 2010| Evista| $682.00 | 2009| Forteo| $518.00 | 2009| Total U.S. sales of competitors:| $2,379.00 | | Prolia is administered by...If you deficiency to get a well(p) essay, order it on our website: Orderessay

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